This upregulation of CA IX expression allows cancer to have a selective advantage in the hypoxia-induced acidic microenvironment, causing an increase in tumor aggression. CAs dysregulation is linked to many diseases, including cancers expressing CA IX. CA II expression is the most widespread in tissue types. Human Carbonic Anhydrases (CAs, EC 4.2.1.1) catalyze the reversible conversion of carbon dioxide and water into bicarbonate and a proton via a coordinated metal ion, typically zinc. Small molecules can be used as a type of precision medicine however, they typically do not have high selectivity for their biological target if it exists in a similar structure or function to other enzymes/receptors. Precision medicine is typically understood as exclusive targeting between closely related enzymatic types/isoforms within the field of medicinal chemistry.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |